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These are thought-about safe if they are ingested (eaten) or utilized to pores and skin. They have not been rated as secure to breathe in, and they may cause lung irritation and allergic reactions. In some situations, they may turn into cancer-causing chemical substances. There is proof that nicotine harms the mind improvement of youngsters. If nicotine is used during pregnancy, it can additionally cause premature births and low birthweight infants.